鄭仁坤, Jen-Kun Cheng, MD, PhD.
E-mail: [email protected]
EDUCATION and TRAINING
July 1983-June 1990, Yang-Ming Medical College, MD, Taipei, Taiwan
July 1992-July 1996, Residency, Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
August 1998- July 1999, Research Fellow, Department of Anesthesiology, Wake Forest University School of Medicine, North Carolina, USA
July 2001-June 2005, Institute of Pharmacology, College of Medicine, National Taiwan University, PhD.
April 18-21, 2006, Preceptorship (ultrasound guided regional anesthesia), Toronto Western Hospital, Canada.
April 22-26, 2006, Workshop (International Society of Ultrasound and Regional Anesthesia, ISURA), Toronto, Canada.
July 2007-June 2008, Research Fellow, Pain Research Center, Department of Anesthesiology, Brigham and Women’s Hospital, Boston, MA, USA
POSITION
August 1996-now, Staff Anesthesiologist, Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan.
2006-now, Assistant Professor, Department of Anesthesiology, Taipei Medical University, Taipei, Taiwan.
July 2009-June 2011, Operating Room Director, Mackay Memorial Hospital, TamShui branch, New Taipei City, Taiwan.
July 2011-now, Chairman, Department of Anesthesiology, Mackay Memorial Hospital, Taipei , Taiwan.
July 2011-now, Operating Room Director, Mackay Memorial Hospital, Taipei , Taiwan.
CERTIFICATION
National Boards of Medical Examiners of R.O.C. # 020173, 1991
Certified, R.O.C. Board of Anesthesiology # 0501, 1996
Acupuncture course training in Veterans General Hospital, Taipei, 1997
Certified, Specialist of Pain Medicine, The Chinese Association for the Study of Pain (IASP Chapter), # 0391, 2002
Certified, Specialist of Cardiac Anesthesia, Taiwan Society of Cardiovascular Anesthesia, # 0024, 2002.
Certified, Instructor for Specialist in Pain Medicine, The Chinese Association for the Study of Pain (IASP Chapter), # 041, 2005
MEMBERSHIPS OF PROFESSIONAL AND SOCIETIES
R.O.C. Board of Anesthesiologists
Taiwan Medical Association
Taipei County Medical Association
Chinese Association for the Study of Pain
Society of Emergency & Critical Care Medicine, Taiwan.
Society for Modern Acupuncture Research
American Society of Anesthesiology
Society for Neuroscience
International Association for the Study of Pain
FIELD of SPECIALTY
Pain research, Ultrasound guided regional anesthesia, Pharmacology.
MAJOR AWARDS and HONORS
Young Investigator Award, Chinese Association for the Study of Pain (Taiwan), 2005.
John J. Bonica Trainee Fellowship Award, International Association for the Study of Pain (IASP), 2006.
Research Potential Award, Chinese Association for the Study of Pain (Taiwan), 2007.
PUBLICATIONS
1. Wen YR, Tan PH, Jen-Kun Cheng, Liu YC, Ji RR. Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc. 2011 Aug;110(8):487-94 (review, SCI)
2. CH wang, CL Yang, HC Lao, Jen-Kun Cheng, CC Chen, CS Lin. Treatment of spontaneous intracranial hypotension secondary to sacral perineural cysts by caudal epidural blood patch – a case report. 2011 21(1): 26-31
3. Li-Chuan Chu, Meei-Ling Tsaur, Chia-Shiang Lin, Yu-Chun Hung, Tao-Yeuan Wang, Chien-Chuan Chen, Jen-Kun Cheng*. Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. British Journal of Anaesthesia 2011 (accepted) (SCI) (*corresponding author)
4. Chiun-Ting Chen, Chih-Lin Yang, Hsuan-Chih Lao, Yung-Wei Hsu,Yu-Chun Hung, Jen-Kun Cheng, Chien-Chuan Chen, Chia-Shiang Lin. Ultrasound-Guided Intercostal Nerve Block for Intractable Right Upper Quadrant Abdominal Pain : A Case Report. Chinese Journal of Pain 2010 20(2):77-82.
5. Chih-Lin Yang, Hsuan-Chih Lao, Yung-Wei Hsu, Yu-Chun Hung, Jen-Kun Cheng, Chien-Chuan Chen, Chia-Shiang Lin. Ultrasound-Guided Pulsed Radiofrequency of Suprascapular Nerve for Chronic Shoulder Pain: A Case Report. 2010 20(2):83-92.
6. Chia-Shiang Lin,* Jen-Kun Cheng,* Yung-Wei Hsu, Chien-Chuan Chen, Hsuan-Chih Lao, Chun-Jen Huang, Peter H. Cheng, Samer Narouze. Ultrasound-Guided Ganglion Impar Block: A Technical Report. Pain Medicine 2010 11(3):390-4. (*first authors of equal contribution) (SCI)
7. Yong-Jing Gao,* Jen-Kun Cheng,* Qing Zeng, Zhen-Zhong Xu, Isabelle Decosterd, Xiaoyin Xu, Ru-Rong Ji. Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. Experimental Neurology 2009 Sep;219(1):146-55. (*first authors of equal contribution) (SCI)
8. Chih-Fu Lin, Meei-Ling Tsaur, Chia-Shiang Lin, Chien-Chuan Chen, Yung-Jen Huang, Jen-Kun Cheng*. Intrathecal gabapentin does not act as an HCN channel activator in the rat formalin test. 2009 European Journal of Anesthesiology 2009;26(10):821-4. (*corresponding author) (SCI)
9. Hung YC, Suzuki S, Chen CC, Pan YY, Wang TY, Jen-Kun Cheng , Wang GK, Gerner P. Calcium chloride prolongs the effects of lidocaine and bupivacaine in rat sciatic nerve. Reg Anesth Pain Med. 2009 34(4):333-9. (SCI)
10. Yasuhiko Kawasaki,* Ling Zhang,* Jen-Kun Cheng, Ru-Rong Ji. Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. Journal of Neuroscience 2008 14;28(20):5189-94. (*first authors of equal contribution) (SCI)
11. Tatsuro Kohno,* Haibin Wang,* Fumimasa Amaya, Gary J. Brenner, Jen-Kun Cheng, Ru-Rong Ji, Clifford J. Woolf. Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. Journal of Neuroscience 2008 23;28(17):4533-40. (*first authors of equal contribution) (SCI)
12. Jen-Kun Cheng, Ru-Rong Ji. Intracellular signaling in primary sensory neurons and persistent pain. Neurochemical Research 2008 33(10):1970-8. (review) (SCI)
13. Li-Ying Chien*, Jen-Kun Cheng*, Dachen Chu, Chau-Fu Cheng, Meei-Ling Tsaur. Reduced Expression of A-type Potassium Channels in Primary Sensory Neurons Induces Mechanical Hypersensitivity. Journal of Neuroscience 2007 27(37):9855-9865. (*first authors of equal contribution) (SCI)
14. Yu-Chun Hung, Chia-Ying Chen, Philipp Lirk, Chi-Fei Wang, Jen-Kun Cheng, Chien-Chuan Chen, Ging Kuo Wang, Peter Gerner. Magnesium sulfate diminishes the effects of amide local anesthetics in rat sciatic nerve block. Regional Anesthesia and Pain Medicine 2007; 32(4):288-95. (SCI)
15. Lin CS, Tsaur ML, Chen CC, Wang TY, Lin CF, Lai YL, Hsu TC, Pan YY, Yang CH, Cheng JK.* Chronic intrathecal infusion of minocycline prevents the development of spinal nerve ligation-induced pain in rats. Regional Anesthesia and Pain Medicine 2007 May-Jun;32(3):209-16. (*corresponding author)
16. Jen-Kun Cheng, Chia-Shiang Lin, Chien-Chuan Chen, Jia-Rung Yang, Lih-Chu Chiou. Effects of Intrathecal Injection of T-Type Calcium Channel Blockers in the Rat Formalin Test. Behavioural Pharmacology 2007; 18(1):1-8. (SCI, supported by NSC 94-2314-B-195 –006)
17. Jen-Kun Cheng, Lih-Chu Chiou. Mechanisms of the antinociceptive action of gabapentin. J Pharmacol Sci 2006;100(5):471-86. (SCI, supported by NSC 94-2314-B-195 –006)
18. Jen-Kun Cheng, Chien-Chuan Chen, Jia-Rung Yang, Lih-Chu Chiou. Antiallodynic action target of intrathecal gabapentin: Ca2+ Channels, KATP channels or NMDA receptors? Anesth Analg 2006;102 (1):182-7. (SCI, supported by NSC 93-2314-B-195-024)
19. Hsin-Yi Huang*, Jen-Kun Cheng*, Yang-Shin Shih, Pei-Hsuan Chen, Chin-Lin Wang, Meei-Ling Tsaur. Expression of A-type K+ channel subunits Kv4.2 and Kv4.3 in rat spinal lamina II excitatory interneurons and co-localization with pain-modulating molecules. European Journal of Neuroscience 2005;22(5):1149-57. (*: first authors, equal contribution, SCI)
20. Chi-Hang Kuok, Jen-Kun Cheng, Kuo-Hwa Wu, Sho-Jen Cheng, Chia-Shiang Lin, Chun-Jen Huang, Chien-Chuan Chen. Refractory trigeminal neuralgia successfully treated with gabapentin — a case report. The Chinese Journal of Pain 2005; 14(2):67-73.
21. Ying-Lun Chen, Chea-Ying Chen, Jen-Kun Cheng. Delayed tension pneumothorax during surgery. Journal of the Chinese Medical Association 2005; 68(10):491-4.
22. Wan-Yu Huang, Jen-Kun Cheng, Chea-Ying Chen, Chen-Hsien Yang, Cheng-Kuei Chang, Chien-Chuan Chen. Successful management of intraoperative sevoflurane-induced malignant hyperthermia: a case report. Journal of Emergency and Critical Care Medicine 2005; 16(4):165-174.
23. Jen-Kun Cheng, Ling-Ling Hwang, Robert Chang-Chih Chou, Lih-Chu Chiou. Analgesic effects of orexins. Journal of Neuropathic Pain & Symptom Palliation 2005; 1(1):47-53.
24. Jen-Kun Cheng, Lee SZ, Yang JR, Wang CH, Liao YY, Chen CC, Chiou LC. Does gabapentin act as an agonist at native GABAB receptors? J Biomed Sci 2004;11(3):346-355. (SCI)
25. Rau RH, Li YC, Jen-Kun Cheng, Chen CC, Ko YP, Huang CJ. Predicting blood pressure change caused by rapid injection of propofol during anesthesia induction with a logistic regression model. Acta Anaesthesiol Taiwan 2004; 42(2):81-86.
26. Jen-Kun Cheng, Robert Chang-Chih Chou, Ling-Ling Hwang, Lih-Chu Chiou. Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain. J Pharmacol Exp Ther 2003; 307(3):1065-1071. (SCI)
27. Jen-Kun Cheng, Yu-Jun Lai, Chien-Chuan Chen, Ching-Rong Cheng, Lih-Chu Chiou. Magnesium chloride and ruthenium red attenuate the antiallodynic effect of intrathecal gabapentin in a rat model of postoperative pain. Anesthesiology 2003; 98:1472-1479.(SCI)
28. Lih-Chu Chiou, Kuang-Chieh Chuang, Shu-Huai Fan, Cheng-Hung How, Jen-Kun Cheng. Does ethanol activate G-protein coupled inwardly rectifying K+ Channels? Neuroreport 2002; 13(1):163-165. (SCI)
29. Tien-Tien Man, Jen-Kun Cheng, Kar-Lok Wong, Chien-Chuan Chen, Ruey-Horng Rau, Kuo-Hwa Wu, Ching-Rong Cheng. Tracheal intubation condition–a comparison between one minute after rocuronium alone, one minute after rocuronium combined with atracurium and one minute after atracurium with rocuronium at one minute priming interval. Acta Anaesthesiol Sin 2002 Dec;40(4):179-83.
30. Pei-Shan Tsai, Jen-Kun Cheng, Martin Marsala, Chung-Ren Lin, Gi-Hong Wen, Lin-Ch.Yang. Intrathecal magnesium sulfate attenuates algogenic behavior and spinal amino acids release after kainic acid receptor activation in rats. Neuroscience Letters 2001; 301:115-118. (SCI)
31. Jen-Kun Cheng, Hui-Lin Pan, James C. Eisenach. Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain. Anesthesiology 2000; 92:1126-1131. (SCI)
32. James C. Eisenach, Patricia Lavand’homme, Chuanyao Tong, Jen-Kun Cheng, Hui-Lin Pan, Raimo Virtanen, Hanna Nikkanen, Robert James. Antinociceptive and hemodynamic effects of a novel 2-adrenergic agonist, MPV-2426, in sheep. Anesthesiology 1999;91:1425-1436. (SCI)
33. Jen-Kun Cheng, Mu-Hsi Pan, Kuo-Hwa Wu, Martin Saiwong Mok, Tze-TaurWei. Epidural phenylephrine attenuates hypotension induced by Alkalinized lidocaine epiduralanesthesia. Anesth Analg 1999; 88:1322-6. (SCI)
34. Jen-Kun Cheng, Yin-Lin Chen, Kwok-Kuen Pang, Mu-His Pan, Kuo-Hwa Wu, Tze-TaurWei. Intraoperative delayed tension pneumothorax after Blunt chest trauma and positive pressure ventilation: a case report. J Emerg Crit Care Med 8(1):37-42,1997.
35. Ren-Kuen Jen (Jen-Kun Cheng), Kar-Lok Wong, Tze-Taur Wei: Cardiac Arrest associated with bone cement-A case report and re1ated risk Factors. J. Orthop Surg ROC12: 352-355, 1995.
36. Jun-Jen Hwang, Yuan-Pi Ko, Ren-Kuen Jen (Jen-Kun Cheng), Yung-Wei Hsu, Ching-Rong Cheng, Tze-Taur Wei, Ching-Ying Yeh: The use of intranasal nitroglycerine to prevent pressor responses during intubation in general anesthesia – a comparison of various doses. Acta Anaesthesiologica Sinica 33(4):205-210,1995.
37. Yuan-Pi Ko, Ching-Rong Cheng, Janne-Chuan Chen, Yung-Wei Hsu, Ren-kuen Jen (Jen-Kun Cheng), Jun-Jen Hwang, Tze-Taur Wei. A proper size of endotracheal tube for infant and young child-a retrospective study in Mackay Memorial Hospital Acta Anaesthesiologica Sinica 33(3):165-171, 1995
38. Janne-Chuan Chen, Ren-kuen Jen (Jen-Kun Cheng), Yung-Wei Hsu, Yuarn-Bih Ke, Jun-Jen Hwang, Kuo-Hwa Wu, Tze-Taur Wei: 4P Syndrome (Wolf-HirschhornSyndrome) complicated with Delay onset of Malignant Hyperthemia: a case report. Acta Anaesthesiologica Sinica 32(4):275-278,1994.
Research Funding
PI
2009-2011：Roles of Na+/Ca2+ exchanger and T-type Ca2+ channel in the development of L5/6 spinal nerve ligation-induced pain (98-2314-B-195-002-MY3) NSC
2005：The Effect of T-type Calcium Channel Blockers on Pain Behaviors and Spinal Fos Expression in the Rat Formalin Test and Neuropathic Pain Model(94-2314-B-195-006) NSC
2004：The Antinociceptive Effects of Intrathecal Na(+) Channel Blockers and Their Interactions with Gabapentin and COX-2 Inhibitor NS-398 in Rat Neuropathic and Inflammatory Pain Models (93-2314-B-195-024) NSC
2003：The role of KATP channel and NMDA receptor in the antinociceptive effects of intrathecal gabapentin in the postoperative pain model (92-2314-B-195-018) NSC
2002：Is gabapentin a GABAB receptor agonist? – approach from pain behavioral study and electrophysiological study (91-2314-B-195-027) NSC
2000：The antinociceptive effects of calcium channel blockers and the possible mechanism of gabapentin in the postoperative pain model (89-2314-B-195-016) NSC
Co-PI:
2006：The role of Kv4 in the nerve injury-induced neuropathic pain model NSC
Public Services:
Councilor, Chinese association for the study of pain
Supervisor, Taiwan Society of Anesthesiologists
Journal Reviewer:
Biochemical Pharmacology, Life Sciences, Anesthesiology,
Taiwanese Journal of Obstetrics and Gynecology, Acta Anaesthesiologica Taiwanica
Editorial Board Members: The Chinese Journal of Pain
NSC project reviewer: 2005,2006,2007,2009,2010.
Renew:2011/08/29